Lactulose breath test for determining oral-caecal transit time
The hydrogen-lactulose breath test is used to assess the rate at which food moves through the digestive tract from the mouth to the beginning of the large intestine (the cecum), as well as to detect possible bacterial overgrowth in the small intestine (SIBO).
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The hydrogen lactulose breath test is used to assess the rate at which food moves through the digestive tract from the mouth to the beginning of the large intestine (the cecum), as well as to detect possible bacterial overgrowth in the small intestine (SIBO).
During the test, the patient must drink a solution of lactulose—a special type of sugar that the human body cannot break down on its own. It reaches the large intestine, where bacteria ferment it, releasing gases—primarily hydrogen and methane. These gases enter the bloodstream and are then exhaled through the lungs. By measuring the levels of these gases in the breath at specific intervals, doctors can assess both the transit time of the intestines and whether there is an excessive amount of bacteria in the small intestine.
The test usually takes about 2–3 hours.
How should I prepare for the test?
- Diet: For 24 hours before the test, it is recommended to eat light meals low in fiber, avoiding fruits, vegetables, beans, whole grains, and nuts.
- Before the exam: Do not eat for 12 hours (only plain water is allowed).
- Medications: Do not take antibiotics, probiotics, laxatives, or medications that may affect bowel movements for at least 2 weeks before the test. You must consult your doctor regarding discontinuing medication.
- Additionally: Refrain from smoking and intense physical activity for 12 hours before the test. The lactulose hydrogen test allows for the assessment of bacterial growth in the middle and distal parts of the small intestine, as well as the measurement of oral-caecal transit time (how quickly food reaches the large intestine).
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